{"id":3786,"date":"2026-07-26T19:17:40","date_gmt":"2026-07-26T19:17:40","guid":{"rendered":"https:\/\/ecokompass.com\/?p=3786"},"modified":"2026-10-08T23:15:16","modified_gmt":"2026-10-08T23:15:16","slug":"psilocibina-alzheimer-avanzado-caso-clinico","status":"publish","type":"post","link":"https:\/\/ecokompass.com\/en\/psilocibina-alzheimer-avanzado-caso-clinico\/","title":{"rendered":"Psilocybin and advanced Alzheimer's: functional improvement in a clinical case"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Vamos a comentar un caso cl\u00ednico real, publicado en mayo de 2026 en la revista <a href=\"https:\/\/doi.org\/10.3389\/fnins.2026.1813281\" target=\"_blank\" rel=\"noopener\"><em>Frontiers in Neuroscience<\/em><\/a>, sobre los efectos de una&nbsp;<strong>high dose of psilocybin<\/strong>&nbsp;in an octogenarian patient with an advanced case of <a href=\"https:\/\/ecokompass.com\/en\/tipos-de-demencia-diagnosticos-sintomas-tratamientos\/\"><strong>Alzheimer's disease<\/strong><\/a>.<br>After the administration of mushrooms containing this compound, the patient experienced a&nbsp;<strong>significant functional improvement<\/strong>&nbsp;, temporary in nature, in areas such as language, mobility and sphincter control.<br><br>This is not really a cure. The intervention facilitated access to&nbsp;<strong>residual cognitive capacities<\/strong>&nbsp;that were considered lost due to the neurodegeneration caused by the disease.<br><br>The authors suggest that this phenomenon could be linked to the&nbsp;<strong>reorganisation of neural networks<\/strong>&nbsp;and to mechanisms of brain plasticity stimulated by the substance. Finally, the study emphasises the need for controlled research to explore further the potential of&nbsp;<strong>psychedelics<\/strong>&nbsp;in the terminal stages of dementia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mejoras funcionales observadas con psilocibina<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">After the administration of <strong>psilocybin<\/strong>, the patient showed significant improvements in multiple functional domains that had been severely impaired for years due to advanced Alzheimer's disease. These improvements included:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Language and communication:<\/strong> Approximately 19 hours after treatment, the patient spontaneously began an <strong>autobiographical talk<\/strong> that lasted several hours. She subsequently showed an increase in spontaneous conversational engagement and greater verbal expressiveness.<\/li>\n\n\n\n<li><strong>Continence:<\/strong> There was a <strong>restoration of urinary continence<\/strong> (dry nappies, even at night), a remarkable improvement given that she had suffered from chronic incontinence for more than 5 years. This improvement persisted even one month after the first session.<\/li>\n\n\n\n<li><strong>Motor capacity:<\/strong> The patient regained <strong>marcha independiente<\/strong> on the second day and showed a general improvement in mobility and agility when walking.<\/li>\n\n\n\n<li><strong>Executive functions and autonomy:<\/strong> She began to show <strong>spontaneous initiative<\/strong>, going so far as to dress herself.<\/li>\n\n\n\n<li><strong>Memory and social cognition:<\/strong> She once again recognised her relatives, recovered contextual memories (such as correctly recognising a vehicle) and maintained working memory for social context (for example, asking about specific people).<\/li>\n\n\n\n<li><strong>Affective and social state:<\/strong> An increase was observed in <strong>capacidad de respuesta emocional<\/strong>, sustained eye contact, reciprocal smiles and the use of spontaneous humour. In addition, the patient verbally expressed that she found it \u201cpleasant\u201d to attend the sessions.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">It is important to stress that, although these improvements were <strong>multi-domain and clinically significant<\/strong>, the study describes them as <strong>transient<\/strong> and they do not imply a reversal of the disease pathology.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cu\u00e1nto duraron las mejor\u00edas<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">La duraci\u00f3n de las mejoras funcionales en la paciente vari\u00f3 seg\u00fan el \u00e1rea afectada, aunque en t\u00e9rminos generales se describen como <strong>transient<\/strong> and many of them persisted for <strong>several weeks<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The detailed timeline of these improvements according to the treatment results was as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Language and autobiographical memory:<\/strong> The spontaneous autobiographical talk emerged about 19 hours after administration and lasted <strong>several hours<\/strong> (approximately 4 hours).<\/li>\n\n\n\n<li><strong>Urinary continence:<\/strong> This was one of the longest-lasting improvements. After regaining it between days 2 and 3, the patient <strong>remained continent for at least one month<\/strong> (including at night), which was a decisive factor in the decision to carry out a second treatment session.<\/li>\n\n\n\n<li><strong>General and social improvements:<\/strong> Various clinical gains (mobility, emotional reciprocity, spontaneous communication and social interaction) were maintained during the <strong>weeks following<\/strong> the first intervention.<\/li>\n\n\n\n<li><strong>Status one month after treatment:<\/strong> One month after the first dose, the patient was still showing a <strong>mejora funcional en comparaci\u00f3n con su estado inicial<\/strong>, retaining continence and a greater capacity for verbal expression and humour after the second session.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Los autores del reporte subrayan que, si bien estas mejoras fueron significativas, lo observado entre psilocibina y Alzheimer en esta paciente no representa una reversi\u00f3n de la patolog\u00eda, sino un acceso temporal a capacidades funcionales residuales.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Course after the second treatment session<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The <strong>second session<\/strong> of treatment was carried out <strong>one month after<\/strong> the first intervention, using a dose of <strong>3 g<\/strong> of psilocybin-containing mushrooms. This session was carried out because the patient still retained significant clinical improvements, such as urinary continence.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The course after this second administration showed the following results:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Greater verbal expressiveness:<\/strong> Unlike the first session, the patient remained significantly more verbally expressive throughout the experience.<\/li>\n\n\n\n<li><strong>Positive emotional content:<\/strong> She spontaneously described autobiographical images with a positive emotional charge, such as surfing with her son on a Pacific island.<\/li>\n\n\n\n<li><strong>Improvements in social and affective interaction:<\/strong> An increase was observed in <strong>facial expressiveness<\/strong>, the <strong>emotional reciprocity<\/strong> and the use of <strong>spontaneous humour<\/strong>.<\/li>\n\n\n\n<li><strong>Motor capacity:<\/strong> There was a reported <strong>greater agility when walking<\/strong>.<\/li>\n\n\n\n<li><strong>The patient's perspective:<\/strong> The patient verbally expressed her well-being during the process, going so far as to say spontaneously: <strong>\u201cIt is pleasant to come here\u201d<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Al igual que en la primera sesi\u00f3n, no se observaron efectos adversos graves, agitaci\u00f3n prolongada, inestabilidad cardiovascular ni deterioro neurol\u00f3gico tras el seguimiento. Los autores se\u00f1alan que estos hallazgos sugieren que las capacidades funcionales latentes en pacientes con Alzheimer avanzado pueden volverse accesibles temporalmente bajo condiciones neuromodulatorias espec\u00edficas.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Qu\u00e9 dosis de psilocibina se administr\u00f3<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In the two documented treatment sessions, the following doses of psilocybin-containing mushrooms (variety <strong>Enigma<\/strong>), administered orally, were used:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>First session:<\/strong> A single dose of <strong>5 g<\/strong> de hongos.<\/li>\n\n\n\n<li><strong>Second session:<\/strong> This was carried out one month after the first intervention using a dose of <strong>3 g<\/strong> de hongos.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">En este caso de psilocibina y Alzheimer avanzado, los autores aclaran que las dosis se consideran <strong>relatively high<\/strong> compared with the protocols commonly used in modern clinical trials, and were selected on the basis of previous observations regarding the depth and duration of neurobehavioural effects in patients with this degree of impairment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Efectos secundarios observados durante la fase aguda<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">During the <strong>acute phase<\/strong> of the first session (the first 12 hours after administration), the following side effects and clinical manifestations were observed:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Autonomic activation:<\/strong> The patient showed signs of an autonomic nervous system response.<\/li>\n\n\n\n<li><strong>Suspected hyperthermia:<\/strong> A clinical suspicion of raised body temperature was identified, although no exact quantitative measurements were available.<\/li>\n\n\n\n<li><strong>Profuse sweating:<\/strong> The patient experienced intense perspiration during this phase.<\/li>\n\n\n\n<li><strong>Deep sleep state:<\/strong> A period of <strong>deep drowsiness<\/strong> and a state resembling prolonged deep sleep were described.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">It is important to stress that, despite these initial reactions, <strong>no serious adverse effects were observed<\/strong>, nor prolonged agitation, clinically significant cardiovascular instability, persistent psychotic symptoms or late neurological deterioration during follow-up.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Psilocibina y Alzheimer: c\u00f3mo se explican sus efectos en el cerebro<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The effect of psilocybin on the brain is explained by a combination of molecular mechanisms, changes in the dynamics of neural networks and plasticity processes:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Receptor activation:<\/strong> Psilocybin acts mainly through the activation of <strong>serotonin 5-HT2A receptors<\/strong>, which triggers marked alterations in brain dynamics.<\/li>\n\n\n\n<li><strong>Reorganisation of neural networks:<\/strong> Neuroimaging studies in humans have shown that its administration produces a <strong>large-scale reorganisation<\/strong>, which includes:\n<ul class=\"wp-block-list\">\n<li>Alteration of the integrity of the <strong>default mode network<\/strong> (Default Mode Network).<\/li>\n\n\n\n<li>Reduced network segregation and broad changes in functional connectivity.<\/li>\n\n\n\n<li>An increase in <strong>global integration<\/strong>, cortical desynchronisation and a transient desegregation of the usual cortical systems.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Promotion of neuroplasticity:<\/strong> Preclinical research suggests that psychedelics of this type can foster <strong>structural and functional plasticity<\/strong>, promoting dendrite growth and synaptic remodelling.<\/li>\n\n\n\n<li><strong>Functional reintegration:<\/strong> In cases of neurodegenerative diseases such as Alzheimer's, it is hypothesised that psilocybin may facilitate the <strong>functional reintegration of residual neural systems<\/strong>. Esto permitir\u00eda que capacidades funcionales que a\u00fan persisten de forma latente en el cerebro se vuelvan temporalmente accesibles bajo estas condiciones espec\u00edficas de neuromodulaci\u00f3n.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Si te interesa c\u00f3mo otras l\u00edneas de investigaci\u00f3n abordan la funci\u00f3n cerebral en el Alzheimer, puedes leer tambi\u00e9n <a href=\"https:\/\/ecokompass.com\/en\/alzheimer-terapia-luz-sonido-investigacion\/\">la terapia de luz y sonido contra el Alzheimer<\/a> y <a href=\"https:\/\/ecokompass.com\/en\/sistema-glinfatico-higiene-del-sueno\/\">el papel del sistema glinf\u00e1tico y la higiene del sue\u00f1o<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Psilocibina y Alzheimer: puntos destacados<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Es un \u00fanico caso cl\u00ednico<\/strong>, no un ensayo controlado: sus resultados no se pueden generalizar a otros pacientes.<\/li>\n\n\n\n<li><strong>Paciente:<\/strong> mujer octogenaria con 10 a\u00f1os de evoluci\u00f3n de Alzheimer, 5 de ellos con deterioro funcional marcado y habla casi monosil\u00e1bica.<\/li>\n\n\n\n<li><strong>Intervenci\u00f3n:<\/strong> 5 g de hongos con psilocibina (variedad Enigma) por v\u00eda oral y, un mes despu\u00e9s, una segunda sesi\u00f3n con 3 g.<\/li>\n\n\n\n<li><strong>Resultados:<\/strong> unas 19 horas despu\u00e9s reapareci\u00f3 el habla autobiogr\u00e1fica espont\u00e1nea y, en los d\u00edas y semanas siguientes, mejoraron la continencia urinaria, la marcha, la capacidad de vestirse sola y la respuesta emocional y social.<\/li>\n\n\n\n<li><strong>Fase aguda:<\/strong> activaci\u00f3n auton\u00f3mica, sospecha de hipertermia, sudoraci\u00f3n profusa y un sue\u00f1o profundo prolongado, sin efectos adversos graves durante el seguimiento.<\/li>\n\n\n\n<li><strong>Lectura correcta:<\/strong> las mejoras fueron transitorias y no suponen una reversi\u00f3n de la enfermedad; los autores plantean que en fases avanzadas puede persistir una capacidad funcional residual y piden estudios controlados.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group has-background is-layout-flow wp-block-group-is-layout-flow\" style=\"background-color:#e8efd8;padding-top:1em;padding-right:1.2em;padding-bottom:1em;padding-left:1.2em\">\n<p class=\"wp-block-paragraph\"><strong>Aviso importante:<\/strong> la psilocibina y los hongos que la contienen son sustancias controladas en Espa\u00f1a. Su uso fuera de la investigaci\u00f3n autorizada no est\u00e1 permitido. Este art\u00edculo tiene fines informativos y divulgativos, no es una recomendaci\u00f3n de uso y no sustituye la valoraci\u00f3n de un profesional sanitario.<\/p>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Referencia<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Lago M, Cerveira M, Simonet JX. <em>Transient multidomain functional improvement in advanced Alzheimer&#8217;s disease following high-dose psilocybin-containing mushroom administration: a case report<\/em>. Frontiers in Neuroscience. 2026;20:1813281. DOI: <a href=\"https:\/\/doi.org\/10.3389\/fnins.2026.1813281\" target=\"_blank\" rel=\"noopener\">10.3389\/fnins.2026.1813281<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Caso cl\u00ednico publicado en Frontiers in Neuroscience (2026): una paciente octogenaria con Alzheimer avanzado tratada con psilocibina. Mejoras observadas, dosis, efectos secundarios y l\u00edmites del hallazgo.<\/p>","protected":false},"author":1,"featured_media":3788,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[180,173,179],"tags":[67,410,409,190],"class_list":["post-3786","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-01-alzheimer","category-portfolio-demencias","category-05-tratamientos-naturales","tag-alzheimer","tag-neuroplasticidad","tag-psicodelicos","tag-psilocibina"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"Una paciente octogenaria con Alzheimer avanzado mejor\u00f3 lenguaje, movilidad y continencia tras tomar psilocibina. 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