{"id":162,"date":"2026-07-14T09:57:34","date_gmt":"2026-07-14T09:57:34","guid":{"rendered":"https:\/\/ecokompass.com\/?p=162"},"modified":"2026-10-08T23:15:06","modified_gmt":"2026-10-08T23:15:06","slug":"glp-1-salud-osea-ozempic-osteoporosis-gota","status":"publish","type":"post","link":"https:\/\/ecokompass.com\/en\/glp-1-salud-osea-ozempic-osteoporosis-gota\/","title":{"rendered":"Ozempic y osteoporosis: el estudio que relaciona los GLP-1 con los huesos y la gota"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Recent research suggests that the use of <strong>GLP-1<\/strong>drugs, such as Ozempic, could be linked to a <strong>moderate increase<\/strong> in the risk of developing <strong>osteoporosis and gout<\/strong>. Aunque estos medicamentos son revolucionarios para tratar la <strong>obesity and diabetes<\/strong>, an observational study detected a higher incidence of <strong>bone weakening<\/strong> in patients who use them.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Experts suggest that <strong>accelerated weight loss<\/strong> and the possible reduction in the intake of <strong>essential nutrients<\/strong> podr\u00edan estar detr\u00e1s de estos efectos. Aun as\u00ed, el <strong>physical exercise<\/strong> y una nutrici\u00f3n adecuada pueden mitigar los riesgos, y los especialistas insisten en una <strong>comprehensive medical supervision<\/strong> para vigilar la salud de los huesos durante el tratamiento.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ozempic y osteoporosis: qu\u00e9 se ha descubierto<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The class of medicines known as <strong>GLP-1<\/strong>, such as <strong>Ozempic and Wegovy<\/strong>, han revolucionado el tratamiento de la diabetes tipo 2 y la obesidad. Sin embargo, a medida que su uso se extiende, la comunidad cient\u00edfica profundiza en sus efectos a largo plazo. Una investigaci\u00f3n presentada en la <strong>reuni\u00f3n anual de 2026 de la Academia Estadounidense de Cirujanos Ortop\u00e9dicos (AAOS)<\/strong> ha puesto el foco en una posible relaci\u00f3n entre estos f\u00e1rmacos y un ligero aumento en el riesgo de <strong>bone problems and gout<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u00bfQu\u00e9 revelan los datos del estudio?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">El estudio analiz\u00f3 los historiales m\u00e9dicos de casi <strong>147.000 adultos<\/strong> con obesidad y diabetes tipo 2 (73.483 usuarios de GLP-1 y otros tantos no usuarios con caracter\u00edsticas similares) durante <strong>cinco a\u00f1os<\/strong>. Al comparar ambos grupos, se encontraron estas diferencias:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Osteoporosis:<\/strong> el <strong>4,1 %<\/strong> de los usuarios de GLP-1 desarrollaron esta enfermedad, frente al 3,2 % del grupo de comparaci\u00f3n. Esto supone un <strong>aumento del 29 % en el riesgo relativo<\/strong>.<\/li>\n\n\n\n<li><strong>Osteomalacia:<\/strong> esta afecci\u00f3n, que reblandece los huesos, fue m\u00e1s del doble de frecuente (0,2 % frente a 0,1 %), aunque sigue siendo muy poco com\u00fan.<\/li>\n\n\n\n<li><strong>Gota:<\/strong> la incidencia fue ligeramente mayor en el grupo de GLP-1 (<strong>7,4 %<\/strong> frente al 6,6 %), un 12 % m\u00e1s de riesgo relativo.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"900\" src=\"https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/ozempic-y-osteoporosis.webp\" alt=\"Ozempic y osteoporosis: gr\u00e1fico del riesgo de osteoporosis, gota y osteomalacia en usuarios de f\u00e1rmacos GLP-1 frente a no usuarios\" class=\"wp-image-4786\" srcset=\"https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/ozempic-y-osteoporosis.webp 1600w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/ozempic-y-osteoporosis-300x169.webp 300w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/ozempic-y-osteoporosis-1024x576.webp 1024w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/ozempic-y-osteoporosis-768x432.webp 768w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/ozempic-y-osteoporosis-1536x864.webp 1536w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/ozempic-y-osteoporosis-18x10.webp 18w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/ozempic-y-osteoporosis-600x338.webp 600w\" sizes=\"auto, (max-width: 1600px) 100vw, 1600px\" \/><figcaption class=\"wp-element-caption\">Riesgo a cinco a\u00f1os en usuarios de GLP-1 frente a no usuarios. Infograf\u00eda: EcoKOMPASS.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">El inter\u00e9s por esta investigaci\u00f3n surgi\u00f3 en la consulta: el cirujano ortop\u00e9dico John G. Horneff, coautor del trabajo, observ\u00f3 pacientes tratados con GLP-1 que sufr\u00edan <strong>lesiones tendinosas importantes<\/strong> tras golpes o esfuerzos menores. Eso sugiri\u00f3 que el f\u00e1rmaco podr\u00eda estar influyendo en los tejidos conectivos y los huesos de forma m\u00e1s amplia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ozempic y osteoporosis: \u00bfpor qu\u00e9 podr\u00edan verse afectados los huesos?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">It is essential to understand that this study was <strong>observational<\/strong>, por lo que no demuestra una relaci\u00f3n de causa y efecto. Adem\u00e1s, por ahora se ha presentado como resumen de congreso y no como art\u00edculo completo revisado por pares. No obstante, los especialistas manejan dos hip\u00f3tesis principales relacionadas con la <strong>rapid weight loss<\/strong>:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Reduced mechanical load:<\/strong> al perder peso de forma acelerada, los huesos reciben menos presi\u00f3n, lo que podr\u00eda desencadenar procesos de <strong>bone remodelling<\/strong> or loss of mineral density.<\/li>\n\n\n\n<li><strong>Nutritional deficit:<\/strong> la disminuci\u00f3n del apetito puede llevar a una menor ingesta de nutrientes cr\u00edticos para el esqueleto, como <strong>calcium, protein and vitamin D<\/strong>.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">In the case of gout, it is believed that rapid weight loss can temporarily raise levels of <strong>uric acid<\/strong> in the blood, which promotes inflammation of the joints.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Balancing benefits and risks<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A pesar de estos hallazgos, los expertos insisten en que la relaci\u00f3n entre Ozempic y osteoporosis debe interpretarse con cautela. Muchos pacientes experimentan <strong>significant musculoskeletal benefits<\/strong> significativos gracias a la p\u00e9rdida de peso, como la reducci\u00f3n del dolor articular y una mejora notable en la movilidad. Por tanto, los nuevos datos no sugieren que estos medicamentos sean peligrosos, sino que subrayan la importancia de un <strong>comprehensive approach<\/strong> to treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">C\u00f3mo proteger tus huesos si usas Ozempic u otro GLP-1<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Si est\u00e1s utilizando medicamentos GLP-1, estas estrategias ayudan a reducir el riesgo:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Structured exercise:<\/strong> en un ensayo cl\u00ednico dan\u00e9s con 195 adultos con obesidad, quienes tomaron un GLP-1 (liraglutida) sin hacer ejercicio perdieron densidad \u00f3sea en la cadera y la columna, mientras que <strong>quienes lo combinaron con ejercicio la conservaron<\/strong> pese a perder m\u00e1s peso. El programa inclu\u00eda bicicleta a intervalos y circuitos de fuerza unas cuatro veces por semana.<\/li>\n\n\n\n<li><strong>Adequate nutrition:<\/strong> asegurar una ingesta suficiente de <strong>prote\u00edna, calcio y vitamina D<\/strong>, ya que el menor apetito puede dificultar cubrir estas necesidades.<\/li>\n\n\n\n<li><strong>Medical supervision:<\/strong> mantener un seguimiento de la salud \u00f3sea durante la p\u00e9rdida de peso, sobre todo si ya existe riesgo de osteoporosis.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Si te interesan las alternativas naturales para el control de la glucosa, puedes leer tambi\u00e9n nuestro an\u00e1lisis sobre la <a href=\"https:\/\/ecokompass.com\/en\/berberina-metformina-natural-evidencia\/\">berberina, la llamada \u00abmetformina natural\u00bb<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ozempic y osteoporosis: puntos destacados<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>En casi 147.000 adultos con diabetes tipo 2 y obesidad, el uso de GLP-1 se asoci\u00f3 a un 29 % m\u00e1s de riesgo de osteoporosis a cinco a\u00f1os.<\/li>\n\n\n\n<li>Tambi\u00e9n aumentaron la gota (un 12 % m\u00e1s) y la osteomalacia, aunque esta sigue siendo muy rara.<\/li>\n\n\n\n<li>Es un estudio observacional presentado en congreso: muestra asociaci\u00f3n, no causa.<\/li>\n\n\n\n<li>Combinar el tratamiento con ejercicio, buena nutrici\u00f3n y control m\u00e9dico ayuda a proteger los huesos.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group has-background is-layout-flow wp-block-group-is-layout-flow\" style=\"background-color:#e8efd8;padding-top:1em;padding-right:1.2em;padding-bottom:1em;padding-left:1.2em\">\n<p class=\"wp-block-paragraph\"><strong>Importante:<\/strong> si usas Ozempic u otro f\u00e1rmaco GLP-1, no lo suspendas ni cambies la dosis por tu cuenta. Comenta con tu m\u00e9dico c\u00f3mo vigilar tu salud \u00f3sea. Este art\u00edculo es divulgativo y no sustituye la valoraci\u00f3n de un profesional sanitario.<\/p>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Aunque los f\u00e1rmacos GLP-1 son herramientas poderosas, su uso debe ir siempre acompa\u00f1ado de cambios saludables en el estilo de vida y de una vigilancia m\u00e9dica estrecha para garantizar que los beneficios superen los posibles riesgos a largo plazo.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Fuentes<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Wajahath M, Lawand JJ, Hill BW, Khan A, Abboud JA, Horneff JG. Estudio sobre el uso de agonistas del receptor GLP-1 y el riesgo de osteoporosis, gota y osteomalacia en adultos con diabetes tipo 2 y obesidad. Resumen presentado en la reuni\u00f3n anual de la AAOS 2026. <a href=\"https:\/\/index.mirasmart.com\/AAOS2026\/PDFfiles\/AAOS2026-008736.pdf\" target=\"_blank\" rel=\"noopener nofollow\">Ver resumen (PDF)<\/a><\/li>\n\n\n\n<li>Jensen SBK, et al. <em>Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial<\/em>. JAMA Netw Open. 2024;7(6):e2416775. DOI: <a href=\"https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.16775\" target=\"_blank\" rel=\"noopener\">10.1001\/jamanetworkopen.2024.16775<\/a><\/li>\n\n\n\n<li>U.S. Pharmacist (2026). <a href=\"https:\/\/www.uspharmacist.com\/article\/glp1-ras-linked-to-higher-risk-of-osteoporosis-gout-osteomalacia\" target=\"_blank\" rel=\"noopener nofollow\"><em>GLP-1 RAs linked to higher risk of osteoporosis, gout, osteomalacia<\/em><\/a>.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Un estudio con casi 147.000 adultos asocia los f\u00e1rmacos GLP-1, como Ozempic, a m\u00e1s riesgo de osteoporosis, osteomalacia y gota. Qu\u00e9 significa y c\u00f3mo proteger los huesos.<\/p>","protected":false},"author":1,"featured_media":214,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"left-sidebar","site-content-layout":"","ast-site-content-layout":"normal-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[60],"tags":[61,64,417,63,62,416],"class_list":["post-162","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicamentos","tag-glp-1","tag-gota","tag-osteomalacia","tag-osteoporosis","tag-ozempic","tag-salud-osea"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"Ozempic y osteoporosis: un estudio con casi 147.000 adultos asocia los GLP-1 a m\u00e1s osteoporosis y gota. 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