{"id":151,"date":"2026-07-10T00:43:11","date_gmt":"2026-07-10T00:43:11","guid":{"rendered":"https:\/\/ecokompass.com\/?p=151"},"modified":"2026-10-08T20:27:21","modified_gmt":"2026-10-08T20:27:21","slug":"inyeccion-experimental-elimina-tumores-cancer-avanzado","status":"publish","type":"post","link":"https:\/\/ecokompass.com\/en\/inyeccion-experimental-elimina-tumores-cancer-avanzado\/","title":{"rendered":"Inyecci\u00f3n contra el c\u00e1ncer: el amivantamab elimina tumores en casos avanzados de cabeza y cuello"},"content":{"rendered":"<p class=\"wp-block-paragraph\">En el mundo de la salud, pocas noticias generan tanta expectativa como las que ofrecen una nueva oportunidad a quienes parec\u00edan haber agotado sus opciones. Una <strong>inyecci\u00f3n contra el c\u00e1ncer<\/strong> llamada <strong>amivantamab<\/strong> ha logrado reducir o eliminar los tumores en casi la mitad de los pacientes con c\u00e1ncer de cabeza y cuello avanzado que ya no respond\u00edan a la quimioterapia ni a la inmunoterapia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El avance se present\u00f3 en la reuni\u00f3n anual de 2026 de la <strong>Sociedad Americana de Oncolog\u00eda Cl\u00ednica (ASCO)<\/strong> y se public\u00f3 a la vez en el <a href=\"https:\/\/doi.org\/10.1200\/JCO-26-01042\" target=\"_blank\" rel=\"noopener\"><em>Journal of Clinical Oncology<\/em><\/a>. Se basa en el ensayo cl\u00ednico internacional <strong>OrigAMI-4<\/strong>, realizado en 11 pa\u00edses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u00bfQu\u00e9 es esta inyecci\u00f3n contra el c\u00e1ncer de \u00abtriple acci\u00f3n\u00bb?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The <strong>amivantamab<\/strong> es un anticuerpo que act\u00faa en tres frentes distintos para combatir la enfermedad:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Blocking growth:<\/strong> inhibe el receptor del factor de crecimiento epid\u00e9rmico (EGFR), una prote\u00edna que alimenta el desarrollo de muchos tumores.<\/li>\n\n\n\n<li><strong>Closing escape routes:<\/strong> bloquea la v\u00eda MET, que algunas c\u00e9lulas cancerosas utilizan para esquivar los tratamientos est\u00e1ndar.<\/li>\n\n\n\n<li><strong>Immune boost:<\/strong> ayuda a <strong>activate the immune system<\/strong> para que identifique y ataque las c\u00e9lulas tumorales.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">Resultados de la inyecci\u00f3n contra el c\u00e1ncer en el ensayo<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">El estudio incluy\u00f3 a <strong>102 pacientes<\/strong> con c\u00e1ncer de cabeza y cuello recurrente o metast\u00e1sico, ya tratados con inmunoterapia y quimioterapia (se excluyeron los tumores de orofaringe asociados al virus del papiloma humano). Estos fueron los resultados:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In <strong>43 pacientes (42 %)<\/strong> el tumor se redujo de forma importante o desapareci\u00f3.<\/li>\n\n\n\n<li>In <strong>15 personas<\/strong> el tumor desapareci\u00f3 por completo de las pruebas.<\/li>\n\n\n\n<li>La respuesta apareci\u00f3 pronto: la mediana fue de <strong>6,6 semanas<\/strong> desde el inicio del tratamiento.<\/li>\n\n\n\n<li>Con casi un a\u00f1o de seguimiento, la mayor\u00eda de las respuestas segu\u00edan activas, incluidas casi todas las completas.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"900\" src=\"https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/inyeccion-contra-el-cancer-amivantamab.webp\" alt=\"Inyecci\u00f3n contra el c\u00e1ncer: gr\u00e1fico de los resultados del amivantamab en 102 pacientes con c\u00e1ncer de cabeza y cuello (15 respuestas completas y 28 parciales)\" class=\"wp-image-4795\" srcset=\"https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/inyeccion-contra-el-cancer-amivantamab.webp 1600w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/inyeccion-contra-el-cancer-amivantamab-300x169.webp 300w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/inyeccion-contra-el-cancer-amivantamab-1024x576.webp 1024w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/inyeccion-contra-el-cancer-amivantamab-768x432.webp 768w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/inyeccion-contra-el-cancer-amivantamab-1536x864.webp 1536w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/inyeccion-contra-el-cancer-amivantamab-18x10.webp 18w, https:\/\/ecokompass.com\/wp-content\/uploads\/2026\/07\/inyeccion-contra-el-cancer-amivantamab-600x338.webp 600w\" sizes=\"auto, (max-width: 1600px) 100vw, 1600px\" \/><figcaption class=\"wp-element-caption\">Resultados del ensayo OrigAMI-4 con amivantamab subcut\u00e1neo. Infograf\u00eda: EcoKOMPASS.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Una inyecci\u00f3n subcut\u00e1nea: menos invasiva, pero con efectos secundarios<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Un aspecto importante de esta inyecci\u00f3n contra el c\u00e1ncer es su forma de administraci\u00f3n. En este ensayo el amivantamab se aplic\u00f3 mediante una <strong>inyecci\u00f3n subcut\u00e1nea cada tres semanas<\/strong>, lo que evita las largas sesiones de infusi\u00f3n intravenosa y permite tratar a los pacientes de forma ambulatoria.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En cuanto a la seguridad, la mayor\u00eda de los efectos secundarios fueron leves o moderados, y solo el <strong>8 %<\/strong> de los participantes tuvo que dejar la terapia por complicaciones. Los m\u00e1s frecuentes fueron los problemas de piel (erupci\u00f3n y lesiones parecidas al acn\u00e9), las inflamaciones alrededor de las u\u00f1as, las llagas en la boca, el cansancio y la bajada de alb\u00famina en sangre. Aun as\u00ed, hubo efectos graves: un paciente muri\u00f3 por una inflamaci\u00f3n pulmonar (neumonitis) relacionada con el tratamiento.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Un caso real: recuperar la vida<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The story of <strong>Carl Walsh<\/strong>, un hombre de 56 a\u00f1os de Birmingham con c\u00e1ncer de lengua, ilustra el impacto humano de este avance. Tras no responder a la quimioterapia ni a la inmunoterapia, entr\u00f3 en el ensayo en el Royal Marsden de Londres en julio de 2025. Con la inyecci\u00f3n, el dolor y la inflamaci\u00f3n disminuyeron, y pudo volver a hablar y a comer con normalidad.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Si te interesan otros avances recientes en oncolog\u00eda, puedes leer tambi\u00e9n sobre la <a href=\"https:\/\/ecokompass.com\/en\/tumores-cerebrales-infantiles-inmunoterapia\/\">inmunoterapia con c\u00e9lulas T en tumores cerebrales infantiles<\/a> o sobre la <a href=\"https:\/\/ecokompass.com\/en\/reversion-del-cancer\/\">cancer reversion<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Inyecci\u00f3n contra el c\u00e1ncer: puntos destacados<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Eficacia en casos dif\u00edciles:<\/strong> el amivantamab redujo o elimin\u00f3 los tumores en 43 de 102 pacientes con c\u00e1ncer de cabeza y cuello avanzado, con desaparici\u00f3n completa en 15.<\/li>\n\n\n\n<li><strong>Triple acci\u00f3n:<\/strong> bloquea EGFR y MET y activa el sistema inmunitario.<\/li>\n\n\n\n<li><strong>Administraci\u00f3n sencilla:<\/strong> una inyecci\u00f3n subcut\u00e1nea cada tres semanas, con respuestas visibles en unas seis semanas.<\/li>\n\n\n\n<li><strong>Tolerancia aceptable:<\/strong> efectos sobre todo en piel, u\u00f1as y boca; un 8 % abandon\u00f3 el tratamiento.<\/li>\n\n\n\n<li><strong>Todav\u00eda experimental:<\/strong> es un ensayo sin grupo de comparaci\u00f3n y har\u00e1n falta estudios m\u00e1s amplios.<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group has-background is-layout-flow wp-block-group-is-layout-flow\" style=\"background-color:#e8efd8;padding-top:1em;padding-right:1.2em;padding-bottom:1em;padding-left:1.2em\">\n<p class=\"wp-block-paragraph\"><strong>Importante:<\/strong> en el c\u00e1ncer de cabeza y cuello, el amivantamab sigue siendo un tratamiento experimental. Este art\u00edculo tiene fines informativos y se basa en resultados de ensayos cl\u00ednicos recientes. Consulta siempre con tu onc\u00f3logo las opciones de tratamiento disponibles, incluidos los ensayos cl\u00ednicos a los que podr\u00edas acceder.<\/p>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Aunque los investigadores se\u00f1alan que se necesitan estudios m\u00e1s amplios para confirmar estos hallazgos, el amivantamab se perfila como una de las l\u00edneas m\u00e1s prometedoras para el c\u00e1ncer de cabeza y cuello resistente a los tratamientos habituales, por su eficacia y por la sencillez de su administraci\u00f3n.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Fuentes<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Burtness B, et al. Ensayo OrigAMI-4 con amivantamab subcut\u00e1neo en carcinoma escamoso de cabeza y cuello recurrente o metast\u00e1sico. Journal of Clinical Oncology. 2026. DOI: <a href=\"https:\/\/doi.org\/10.1200\/JCO-26-01042\" target=\"_blank\" rel=\"noopener\">10.1200\/JCO-26-01042<\/a><\/li>\n\n\n\n<li>Registro del ensayo en ClinicalTrials.gov: <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06385080\" target=\"_blank\" rel=\"noopener nofollow\">NCT06385080<\/a><\/li>\n\n\n\n<li>Targeted Oncology (2026). <a href=\"https:\/\/www.targetedonc.com\/view\/sc-amivantamab-achieves-strong-response-rate-in-hnscc\" target=\"_blank\" rel=\"noopener nofollow\"><em>SC amivantamab achieves strong response rate in HNSCC<\/em><\/a>.<\/li>\n\n\n\n<li>The Irish Times (30\/05\/2026). <a href=\"https:\/\/www.irishtimes.com\/world\/uk\/2026\/05\/30\/cancer-jab-can-eradicate-entire-tumours-in-patients-trial-shows\/\" target=\"_blank\" rel=\"noopener nofollow\"><em>Cancer jab can eradicate entire tumours in patients, trial shows<\/em><\/a>.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Una inyecci\u00f3n contra el c\u00e1ncer de \u00abtriple acci\u00f3n\u00bb, el amivantamab, redujo o elimin\u00f3 los tumores en 43 de 102 pacientes con c\u00e1ncer de cabeza y cuello que ya no respond\u00edan a otros tratamientos.<\/p>","protected":false},"author":1,"featured_media":204,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"left-sidebar","site-content-layout":"","ast-site-content-layout":"normal-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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